| Woody Harrelson | ... One Eyed Jack Faro |
| David Cross | ... Larry Schwartzman |
| Dennis Farina | ... LBJ "Deuce" Fairbanks |
| Cheryl Hines | ... Lainie Schwartzman |
| Richard Kind | ... Andy Andrews |
| Chris Parnell | ... Harold Melvin |
| Jason Alexander | ... Dr. Yakov Achmed |
| Ray Romano | ... Fred Marsh |
| Mike Epps | ... Reggie Marshall |
| Judy Greer | ... Sharon Andrews |
| Werner Herzog | ... The German |
| Gabe Kaplan | ... Seth Schwartzman |
| Michael Karnow | ... Mike Werbe |
| Michael McKean | ... Steve Lavisch |
|
| Julie Claire | ... Dr. Jamie Sellers |
| Barry Corbin | ... Jimminy "Lucky" Faro |
| Shannon Elizabeth | ... Toni |
| Estelle Harris | ... Ruth Melvin |
| Andrew Hill Newman | ... Russell Kalenich (The Dealer) |
| Andrea Savage | ... Renee Jensen |
|
| Phil Gordon | ... Himself |
| Robert Thompson | ... Himself (Tournament Director) |
| Andy Bellin | ... Poker Pro |
| Doyle Brunson | ... Poker Pro |
| Antonio Esfandiari | ... Poker Pro |
| Phil Hellmuth, Jr. | ... Poker Pro |
| Phil Laak | ... Poker Pro |
| Daniel Negreanu | ... Poker Pro |
| Hank Azaria | ... Mike "The Bike" Heslov |
| Tom Hodges | ... Tim "Tiny Wonders" Woolrich |
| David Pressman | ... Melville "Murph Murph" Murphy |
| Brett Ratner | ... "Sob Story" Barry Blaustein |
| Avi Arad | ... Abdul Shavit |
| K. D. Aubert | ... Julie the Waitress |
| Tommy "Tiny" Lister | ... German's Bodyguard |
| Lance Stockton | ... German's Bodyguard |
| Tim Mikuletky | ... Bitch Slapped Man |
| Trula Marcus | ... Front Desk Clerk |
| Cynthia Petrello | ... Waitress at Vic & Anthony's |
| Linda Button | ... Jack's Secretary |
| Rusty Meyers | ... Long Island Poker Player |
| Richard Brodie | ... Himself |
| Peter O'Meara | ... Dave Esme |
| Tara G. Wise | ... Lainie's Daughter Ellen |
| Catherine Rose Young | ... Lainie's Daughter Catherine |
| Alec Holden | ... Little Larry |
| Hailey McCann | ... Little Lainie |
| Orly Shani | ... Lavisch's Assistant |
| Naomi Fabe | ... Lavisch's Assistant |
| Errol Guidry II | ... Cajun Larry |
| Jeff Bowler | ... Poker Player |
| Sharon Fann | ... Dealer at TV Tournament |
| Marc J. Chaiet | ... Hotel Guest |
| Garret McKechnie | ... Hotel Guest |
| Tilman J. Fertitta | ... Himself |
| Munchkin the Rabbit | ... Himself |
