| Jennifer Aniston | ... Annie Hughes (voice) |
| Harry Connick, Jr. | ... Dean McCoppin (voice) |
| Vin Diesel | ... The Iron Giant (voice) |
| James Gammon | ... Foreman Marv Loach / Floyd Turbeaux (voice) |
| Cloris Leachman | ... Mrs. Tensedge (voice) |
| Christopher McDonald | ... Kent Mansley (voice) |
| John Mahoney | ... Gen. Rogard (voice) |
| Eli Marienthal | ... Hogarth Hughes (voice) |
| M. Emmet Walsh | ... Earl Stutz (voice) |
|
| Jack Angel | ... Additional Voices (voice) |
| Robert Bergen | ... Additional Voices (voice) |
| Mary Kay Bergman | ... Additional Voices (voice) |
| Michael Bird | ... Additional Voices (voice) |
| Devon Borisoff | ... Additional Voices (voice) |
| Rodger Bumpass | ... Additional Voices (voice) |
| Robert Clotworthy | ... Additional Voices (voice) |
| Jennifer Darling | ... Additional Voices (voice) |
| Zack Eginton | ... Additional Voices (voice) |
| Paul Eiding | ... Additional Voices (voice) |
| Bill Farmer | ... Additional Voices (voice) |
| Charles Howerton | ... Additional Voices (voice) |
| Ollie Johnston | ... Additional Voices (voice) |
| Sherry Lynn | ... Additional Voices (voice) |
| Mickie T. McGowan | ... Additional Voices (voice) |
| Ryan O'Donohue | ... Additional Voices (voice) |
| Phil Proctor | ... Additional Voices (voice) |
| Frank Thomas | ... Additional Voices (voice) |
| Patti Tippo | ... Additional Voices (voice) |
| Brian Tochi | ... Additional Voices (voice) |
