| Brad Pitt | ... Mills |
| Morgan Freeman | ... Somerset |
|
| Gwyneth Paltrow | ... Tracy |
| Richard Roundtree | ... Talbot |
| R. Lee Ermey | ... Police Captain |
| John C. McGinley | ... California |
|
| Julie Araskog | ... Mrs. Gould |
| Mark Boone Junior | ... Greasy FBI Man |
| John Cassini | ... Officer Davis |
| Reginald E. Cathey | ... Dr. Santiago |
| Peter Crombie | ... Dr. O'Neill |
| Hawthorne James | ... George the Night Guard at the Library |
| Michael Massee | ... Man in Massage Parlor Booth |
| Leland Orser | ... Crazed Man in Massage Parlor |
| Richard Portnow | ... Dr. Beardsley |
| Richard Schiff | ... Mark Swarr |
| Pamala Tyson | ... Vagrant by John Doe's Apartment |
|
| Kevin Spacey | ... John Doe |
|
| Andy Walker | ... Dead Man at Crime Scene |
| Daniel Zacapa | ... Det. Taylor at First Murder |
| Bob Mack | ... Gluttony Victim |
| George Christy | ... Workman at Door of Somerset's Office |
| Endre Hules | ... Cab Driver |
| Roscoe Davidson | ... First Guard at the Library |
| Bob Collins | ... Second Guard at the Library |
| Jimmy Dale Hartsell | ... Library Janitor |
| Charline Su | ... TV News Reporter |
| Dominique Jennings | ... TV News Reporter |
| Allan Kolman | ... First Forensic Man at the Law Office |
| Beverly Burke | ... TV Anchor Woman |
| Gene Borkan | ... Eli Gould -- Greed Victim |
| Mario Di Donato | ... Fingerprint Forensic Man in Law Office |
| Alfonso Freeman | ... Fingerprint Technician |
| Harrison White | ... Cop on SWAT Team |
| Robert Stephenson | ... Cop on SWAT Team |
| Michael Reid MacKay | ... Victor -- Sloth Victim |
| Tudor Sherrard | ... Coupon Man Outside Pizza Parlor |
| Lennie Loftin | ... Policeman Who Takes Statement from Vagrant |
| Sarah Hale Reinhardt | ... Police Sketch Artist |
| Emily Wagner | ... Det. Sara at John Doe's Apartment |
| Martin Serene | ... Wild Bill |
| David Correia | ... First Cop at Massage Parlour |
| Ron Blair | ... Second Cop at Massage Parlour |
| Cat Mueller | ... Lust Victim |
| Lexie Bigham | ... Sweating Cop at Massage Parlor |
| Evan Miranda | ... Paramedic at Massage Parlor |
| Paul S. Eckstein | ... Paramedic at Massage Parlor |
| Harris Savides | ... 911 Operator |
| Rachel Schadt | ... Additional 911 Operator |
| Heidi Schanz | ... Pride Victim |
| Brian Evers | ... Duty Sergeant |
| Shannon Wilcox | ... Woman Cop Behind Desk |
| Jim Deeth | ... Helicopter Pilot |
| John Santin | ... Helicopter Pilot |
| Charles Tamburro | ... SWAT Helicopter Pilot |
| Richmond Arquette | ... Delivery Man |
| Duffy Gaver | ... Marksman in Helicopter |
