| Hayden Panettiere | ... Red Riding Hood (voice) |
| Glenn Close | ... Granny (voice) |
| Patrick Warburton | ... The Big Bad Wolf (voice) |
| Joan Cusack | ... Verushka the Witch (voice) |
| David Ogden Stiers | ... Nicky Flippers (voice) |
| Bill Hader | ... Hansel (voice) |
| Amy Poehler | ... Gretel (voice) |
| Martin Short | ... Kirk the Woodsman (voice) |
| Cory Edwards | ... Twitchy (voice) |
| Brad Garrett | ... The Giant (voice) |
| Andy Dick | ... Boingo the Bunny (voice) |
| David Alan Grier | ... Moss the Troll (voice) |
| Wayne Newton | ... Jimmy 10-Strings (voice) |
|
| The Three Little Hench Pigs |
| Cheech Marin | ... Mad Hog (voice) |
| Tommy Chong | ... Stone (voice) |
| Phil LaMarr | ... Wood (voice) |
|
| Benjy Gaither | ... Japeth the Goat (voice) |
| Danny Pudi | ... Little Boy Blue (voice) |
| Debra Wilson | ... Iana (voice) |
| Tress MacNeille | ... Vera (voice) |
| Heidi Klum | ... Heidi (voice) |
| Clarissa Jacobson | ... Pig (voice) |
| Mike Disa | ... Helmut (voice) |
| Rob Paulsen | ... Johann (voice) |
| Lance Holt | ... Klaus (voice) |
| Tress MacNeille | ... Woman's Voice (voice) |
| Robert Anich | ... Veronica Rhino (voice) |
| Mike Disa | ... Spider, Rhino, HEA Agent 1 & 2 (voice) |
| Rebecca Andersen | ... Radio Voice (voice) |
|
| Voiceover Actors |
| Kirk Baily | ... Voiceover |
| Jack Blessing | ... Voiceover |
| Melendy Britt | ... Voiceover |
| June Christopher | ... Voiceover |
| Brian T. Delaney | ... Voiceover |
| Mike Disa | ... Voiceover |
| Nicholas Guest | ... Voiceover |
| Kyle Herbert | ... Voiceover |
| Bridget Hoffman | ... Voiceover |
| Sandra Holt | ... Voiceover |
| Erin Lander | ... Voiceover |
| Wendee Lee | ... Voiceover |
| Al Rodrigo | ... Voiceover |
| Stephanie Sheh | ... Voiceover |
| Keith Silverstein | ... Voiceover |
| Marcelo Tubert | ... Voiceover |
| Kari Wahlgren | ... Voiceover |
| Lisa Wilhoit | ... Voiceover |
