| Adam Brody | ... Stephen Montgomery |
| Bobby Cannavale | ... Marty McBride |
| Rob Corddry | ... Duane Rosenblum |
| Famke Janssen | ... Gretchen Reigert |
| Kerri Kenney | ... Bernice Jaffe |
| Joe Lo Truglio | ... Paul Mardino |
| Ken Marino | ... Dr. Glenn Richie |
| A. D. Miles | ... Oliver Jennings |
| Gretchen Mol | ... Gloria Jennings |
| Oliver Platt | ... Marc Jacobson |
| Paul Rudd | ... Jeff Reigert |
| Winona Ryder | ... Kelly La Fonda |
| Liev Schreiber | ... Ray Johnson |
| Ron Silver | ... Fielding Barnes |
| Justin Theroux | ... Jesus H. Christ |
| Mather Zickel | ... Louis La Fonda |
| Michael Ziegfeld | ... Harlan Swallow |
|
| Jessica Alba | ... Liz Anne Blazer |
| H. Jon Benjamin | ... Lying Rhino (voice) |
| Reed Birney | ... Jim Stansel |
| Michael Ian Black | ... Prison Guard Jamberg Saivon |
| David Diaan | ... Landlord Izzy Mavis |
| Arlen Escarpeta | ... Todd Jaffe |
| Ben Garant | ... Himself |
| Janeane Garofalo | ... Nuclear Powerplant Shift Supervisor Beth Soden |
| Jerry Grayson | ... Junkie Floyd Congril Dillon |
| Zandy Hartig | ... Sally Johnson / Callie Mardino |
| Nina Hellman | ... Nurse Nancy Hellman |
| Thomas Lennon | ... Scotty Pale |
| Philip Levy | ... Junkie Tommy "Thomas" McKee |
| Paco Mauri | ... Alfonso Zavala |
| Michael Mulheren | ... Carvin "Big Buster" Waggie |
| Novella Nelson | ... Judge Sophia R. Jackson |
| Zak Orth | ... Prosecutor / Tour Guide Barge Michaelson |
| Cedric Sanders | ... Greg Jaffe |
| Michael Showalter | ... Police Lt. Flarn Bleern |
| Jason Sudeikis | ... Tony Contiella |
| John Tormey | ... Junkie Jerry Park |
| David Wain | ... Abe Grossman |
|
| Jon Hamm | ... Skydiving Guide Chris Knarl |
| Todd Holoubek | ... Camera Man Stuart Blumberg |
| Ali Marsh | ... "Entertainment Beat" Host George Reardon |
| Raisy Pereyra | ... Dorothy Sheen |
| Edmond Genest | ... Gov. Beaumont Hutchins |
| Heidi Neurauter | ... Helen Campbell-Holland |
| Jason Antoon | ... Salazar "Fred" McBairn |
| Andrea Rosen | ... Polly "Carol" Samuels |
| Chris Wylde | ... Kevin Lipworth |
| Siri Baruc | ... Party Girl Natalie Freyberg |
| Erica Oyama | ... Breem Benson |
| Alfredo Gonzalez | ... Pedicab Driver |
| Victoria Perez | ... Rosa Zavala |
| Fernando Baena | ... Mango Vendor Rodriguez Rodriguez |
| Tommy Nelson | ... Noah Jennings |
| Beth Dover | ... Sheila Contiella |
| Matthew Ballard | ... Defense Attorney Greg Splenda |
| Scott Sowers | ... Jury Foreman Barry Noodle |
| Kevin Allison | ... Stanley Jaffe |
| Charlie McDermott | ... Jake Johnson |
| Zach Page | ... Loofie Lavinsky |
| Antonio Zavala Kugler | ... Prison Guard Carlos Lopez "Gonzalez" Banderas |
| Rashida Jones | ... Hostess Rebecca Fornier |
| Joe Passaro | ... Xylophone Player Clovis Handleman |
| Zandy Hartig | ... Cartoon Voice (voice) |
| Ken Marino | ... Cartoon Voice (voice) |
| Jonathan Stern | ... Cartoon Voice (voice) |
| David Wain | ... Cartoon Voice (voice) |
| Peter Salett | ... Lying Rhino Body |
| Andrew Dawson | ... Principal DiBiaso |
|
| Naked Guys |
| John Patrick Barry | ... Naked Guy |
| Fred Basco | ... Naked Guy |
| Village Dumetz | ... Naked Guy |
| Jack Fisher | ... Naked Guy |
| Seth Herzog | ... Naked Guy |
| Andy Kaufman | ... Naked Guy |
| Richard Kessler | ... Naked Guy |
| Morris S. Levy | ... Naked Guy |
| Tom McHugh | ... Naked Guy |
| Phil Michas | ... Naked Guy |
| Peter Moore | ... Naked Guy |
| David Ressel | ... Naked Guy |
| Noam Rosen | ... Naked Guy |
| Sarge | ... Naked Guy |
| Jonathan Stern | ... Naked Guy |
| Eric Tepper | ... Naked Guy |
| Craig Wedren | ... Naked Guy |
