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Alfred G. Gilman

Alfred G. GilmanAKA Alfred Goodman Gilman

Born: 1-Jul-1941
Birthplace: New Haven, CT
Died: 23-Dec-2015
Cause of death: Cancer - Pancreatic

Gender: Male
Religion: Jewish
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Scientist, Doctor

Nationality: United States
Executive summary: G-protein cell signal transmission

American pharmacologist Alfred G. Gilman studied cell communication, the means by which information from the beyond a specific cell is conveyed to within that cell through a complex chain of events. He discovered G-proteins, so named because they bind to guanine nucleotides, a key component of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). A crucial intermediary between receptors on the cell membrane and subsequent actions inside the cell, G-proteins are believed to be involved in cellular activities from mating in the lowest yeast to the thought process in the human mind, and faulty G-proteins are implicated in diseases from alcoholism to whooping cough. He was awarded the Nobel Prize in Medicine in 1994, sharing a $930,000 cash stipend with biochemist Martin Rodbell, who conducted separate but related research at the National Institutes of Health.

Gilman's father was a Professor of Chemistry at Yale and later Columbia, and co-authored a textbook with a friend, Dr Louis S. Goodman -- from whom Gilman got his middle name. As a boy, his interest in science was aroused in his father's laboratory, and as a young man he studied at Case Western under Nobel laureate Earl W. Sutherland, Jr., and worked at the National Institutes of Health under another Nobel winner, Marshall W. Nirenberg. Gilman also edited the sixth through tenth editions of the textbook his father co-authored, Goodman and Gilman's The Pharmacological Basis of Therapeutics.

Father: Alfred Gilman (chemistry professor at Yale)
Mother: Mabel Schmidt Gilman (pianist)
Sister: Joanna Gilman
Wife: Kathryn Hedlund Gilman (until his death)
Daughter: Amy
Daughter: Anne
Son: Theodore ("Ted")

    High School: The Taft School, Watertown, CT
    University: BS Biochemistry, Yale University (1962)
    University: PhD Pharmacology, Case Western Reserve University (1969)
    Medical School: MD, Case Western Reserve University (1969)
    Scholar: Pharmacology, National Institutes of Health (1969-71)
    Teacher: Pharmacology, University of Virginia (1971-79)
    Professor: Pharmacology, University of Virginia (1979-81)
    Professor: Pharmacology, University of Texas at Dallas (1981-)
    Dean: Southwestern Medical School, University of Texas at Dallas (2005-)

    Lasker Award 1989
    Nobel Prize for Medicine 1994 (with Martin Rodbell)
    Federation of American Scientists Board of Sponsors
    National Academy of Sciences
    Scientists and Engineers for America
    Member of the Board of Eli Lilly (1995-)
    GlaxoSmithKline Lab worker (1962, at Glaxo predecessor Wellcome)

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