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Michael S. Brown

Michael S. BrownAKA Michael Stuart Brown

Born: 13-Apr-1941
Birthplace: Brooklyn, NY

Gender: Male
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Biologist
Party Affiliation: Democratic

Nationality: United States
Executive summary: Metabolism of cholesterol

American geneticist Michael S. Brown studied cholesterol metabolism, elucidating and analyzing the path of cholesterol as it passes through the human body. Working with Joseph L. Goldstein at Southwestern Medical School, he made major breakthroughs in the scientific understanding of familial hypercholesterolemia, a hereditary disease which elevates the cholesterol level in the blood. In several papers published beginning in 1974, Brown and Goldstein showed that patients with homozygous hypercholesterolemia tend to have high levels of low-density lipoprotein (LDL), and that these patients lack an LDL receptor. They also identified and located the specific gene responsible for LDL receptor production, and discovered the gene mutations responsible for familial hypercholesterolemia and other inherited cholesterol metabolism conditions. In addition to his research, Brown has remained a practicing MD. With Goldstein, he won the Nobel Prize for Medicine in 1985.

Father: Harvey Brown (textile salesman)
Mother: Evelyn Katz Brown (homemaker)
Sister: Susan (b. 1944)
Wife: Alice Lapin (childhood sweetheart, m. 21-Jun-1964, two daughters)
Daughter: Elizabeth (b. 1973)
Daughter: Sara (b. 1977)

    High School: Cheltenham High School, Elkins Park, PA (1958)
    University: BS Chemistry, University of Pennsylvania (1962)
    Medical School: MD, University of Pennsylvania (1966)
    Teacher: Southwestern Medical School, University of Texas at Dallas (1971-76)
    Professor: Internal Medicine, University of Texas at Dallas (1971-76)
    Professor: Paul J. Thomas Professor of Genetics, University of Texas at Dallas (1977-85)
    Professor: Regental Professor, University of Texas at Dallas (1985-)

    David L. Drabkin Prize in Biochemistry 1962
    Boehringer Ingelheim's Heinrich Wieland Prize 1974 (with Joseph L. Goldstein)
    ACS Pfizer Award 1976 (with Joseph L. Goldstein)
    NYSMS Albion O. Bernstein Award 1977 (with Joseph L. Goldstein)
    NAS Richard Lounsbery Award 1979 (with Joseph L. Goldstein)
    Gairdner Foundation International Award 1981 (with Joseph L. Goldstein)
    New York Academy of Sciences Award 1981 (with Joseph L. Goldstein)
    APS Lita Annenberg Hazen Award 1982 (with Joseph L. Goldstein)
    AAMC Distinguished Research Award 1984 (with Joseph L. Goldstein)
    AHA Research Achievement Award 1984 (with Joseph L. Goldstein)
    Louisa Gross Horwitz Prize 1984 (with Joseph L. Goldstein)
    Roche Institute V.D. Mattia Award 1984 (with Joseph L. Goldstein)
    3M Life Sciences Award 1985 (with Joseph L. Goldstein)
    ASHG William Allan Award 1985 (with Joseph L. Goldstein)
    Lasker Award 1985 (with Joseph L. Goldstein)
    Nobel Prize for Medicine 1985 (with Joseph L. Goldstein)
    National Medal of Science 1988
    National Institutes of Health Researcher (1968-71)
    Member of the Board of Pfizer (1996-)
    Member of the Board of Regeneron (1991-)
    American Academy of Arts and Sciences
    American Board of Internal Medicine
    American College of Physicians
    American Heart Association Established Investigator, 1974-77
    American Society for Cell Biology
    American Society for Clinical Investigation
    American Society for Biochemistry and Molecular Biology
    Association of American Physicians
    Jane Coffin Childs Memorial Fund Scientific Adviser, 1980-
    Massachusetts General Hospital Internship, 1966-68
    National Academy of Sciences 1980
    Obama for America
    Research!America Scientific Advisory Committee
    Arteriosclerosis Editorial Board
    Journal of Cell Biology Editorial Board
    Journal of Lipid Research Editorial Board
    Science Editorial Board
    Alpha Omega Alpha Honor Society
    Phi Beta Kappa Society
    Jewish Ancestry

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