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John H. Gaddum

AKA John Henry Gaddum

Born: 31-Mar-1900
Birthplace: Hale, Cheshire, England
Died: 30-Jun-1965
Location of death: Cambridge, Cambridgeshire, England
Cause of death: unspecified

Gender: Male
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Scientist

Nationality: England
Executive summary: Drug antagonism

Military service: British Army (to Lt. Col., 1940-42)

British pharmacologist John H. Gaddum worked under Henry Dale at the National Institute for Medical Research, and helped develop the classical laws of drug antagonism. He showed that sympathetic nerves release adrenaline, and in collaboration with Ulf von Euler established the release of acetylcholine in autonomic ganglia. In experiments with lysergic acid diethylamide (LSD), Gaddum explained how it causes mental disturbances by blocking serotinin's stimulation effects. He also authored an advanced pharmacology text which was considered definitive for decades.

Father: Henry Gaddum (silk merchant)
Mother: Phyllis Gaddum
Wife: Iris Mary Harmer (m. 1929)

    High School: Moorland House School, Heswall, Cheshire, England (1913)
    University: Rugby School, Rugby, Warwickshire, England (1919)
    University: BS Physiology, Cambridge University (1922)
    Medical School: MD, University College London (1925)
    Professor: Pharmacology, Cairo University (1933-35)
    Professor: Pharmacology, University College London (1935-38)
    Professor: Pharmacology, University of London (1938-42)
    Professor: Pharmacology, University of Edinburgh (1942-58)
    Administrator: Director of the Institute of Animal Physiology (1958-65)

    Knight of the British Empire 1964
    British Pharmacological Society
    Royal Society
    Glaxo Wellcome Wellcome Research Laboratories
    National Institute for Medical Research (1927-33)
    Austrian Ancestry (Paternal)
    English Ancestry

Author of books:
Pharmacology (1940)

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