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Irwin Rose

AKA Irwin Allan Rose

Born: 16-Jul-1926
Birthplace: Brooklyn, NY
Died: 2-Jun-2015
Location of death: Deerfield, MA
Cause of death: unspecified

Gender: Male
Religion: Jewish
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Scientist

Nationality: United States
Executive summary: Ubiquitin-mediated protein degradation

Military service: US Navy (radio technician, WWII)

Irwin "Ernie" Rose discovered ubiquitin-mediated protein degradation, the means by which the cells of most living things discard unnecessary proteins. Some diseases are caused when the protein-degradation system fails or malfunctions, and a better understanding of this phenomenon has led to the development of better drugs to combat cancer, cystic fibrosis, Alzheimerís and Parkinsonís diseases. Rose conducted his research at the Fox Chase Cancer Center in Philadelphia, with Aaron Ciechanover and Avram Hershko collaborating over the course of several summer and sabbatical visits in Rose's laboratory. All three scientists shared the Nobel Prize in Chemistry in 2004.

Rose served in the Navy during World War II, and attended college under the G.I. Bill. After more than three decades at Fox Chase he retired in 1995, then accepted an offer of a research position at University of California at Irvine two years later. His wife, Zelda Budenstein Rose, was also a respected biochemist, and spent her career studying the metabolism of red blood cells.

Father: Harry Royze (owned flooring shop)
Mother: Ella Greenwald Royze
Wife: Zelda Budenstein Rose (biochemist-activist, three sons, one daughter)
Son: Frederic
Son: Howard
Son: Robert
Daughter: Sarah (d. 2005)

    High School: Lewis and Clark High School, Spokane, WA (1943)
    University: Washington State University (attended 1943-47)
    University: BS Biochemistry, University of Chicago (1948)
    University: PhD Biochemistry, University of Chicago (1952)
    Scholar: Medicine, Case Western Reserve University (1952-53)
    Scholar: Pharmacology, New York University (1953-54)
    Teacher: Biochemistry, Yale School of Medicine (1954-63)
    Scholar: Fox Chase Cancer Center (1963-95)
    Teacher: Medicine, University of California at Irvine (1995-)

    Nobel Prize for Chemistry 2004 (with Aaron Ciechanover and Avram Hershko)
    National Academy of Sciences
    Hungarian Ancestry Maternal
    Jewish Ancestry
    Russian Ancestry Paternal

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