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Stanford Moore

Stanford MooreBorn: 4-Sep-1913
Birthplace: Chicago, IL
Died: 23-Aug-1982
Location of death: New York City
Cause of death: Lou Gehrig's Disease

Gender: Male
Race or Ethnicity: White
Occupation: Chemist

Nationality: United States
Executive summary: Amino-acid analyzer

Military service: Office of Scientific Research Development (1942-45)

Stanford Moore was named for Stanford University, where his parents met, but he preferred to be called Stan. Born in Chicago and raised in Nashville, where his father was a law professor, he attended the prestigious Peabody Demonstration School (now University School of Nashville), earned his degree at Vanderbilt and his doctorate at the University of Wisconsin. He then joined the Rockefeller Institute for Medical Research (now Rockefeller University), where he proved himself a brilliant scholar and was eventually given increasing freedom to pursue whatever scientific questions drew his curiosity.

He used and created new applications of chromatography to analyze the amino acids and peptides found in proteins and biological fluids. In 1948 he developed a photometric ninhydrin method for use in the chromatography of amino acids, and with his colleague William H. Stein he developed a method of automated amino acid analysis in 1958. By 1963 Moore and Stein had determined the structure and sequence of the ribonuclease (RNase), the first enzyme to have its structure so thoroughly known. With Stein and with Christian Anfinsen, who conducted similar work independently, Moore won the Nobel Prize for Chemistry in 1972.

He never married, and colleagues said that Moore preferred to avoid any entanglements or events that did not involve science or scientists. One of his few non-scientific concerns was brought about by civic responsibility, when in the early 1960s he was selected to serve on a federal grand jury investigating the Cosa Nostra (organized crime). He suffered from amyotrophic lateral sclerosis, a progressive nerve and muscle degeneration commonly known as Lou Gehrig's Disease, which left him largely homebound in his last few years and took his life in 1982. He left his estate to Rockefeller University, "to be used as endowment toward the salary or research expenses or both of an investigator in the field of biochemistry".

Father: John Howard Moore (law professor at Vanderbilt University, b. 10-Dec-1880, d. 1966)
Mother: Ruth Fowler Moore (b. 1881, m. 1907)

    University: University School of Nashville, Nashville, TN (1931)
    University: BA Chemistry, Vanderbilt University (1935, summa cum laude)
    University: PhD Organic Chemistry, University of Wisconsin at Madison (1938)
    Scholar: Chemistry, Rockefeller Institute for Medical Research (1939-42)
    Teacher: Chemistry, Rockefeller Institute for Medical Research (1942-50)
    Scholar: Francqui Chair, University of Brussels (1950)
    Scholar: Chemistry, University of Cambridge (1950-51)
    Scholar: Biochemistry, Rockefeller Institute for Medical Research (1951-52)
    Professor: Biochemistry, Rockefeller Institute for Medical Research (1952-65)
    Professor: Biochemistry, Rockefeller University (1965-82)
    Administrator: Trustee, Vanderbilt University (1974-82)

    ACS Award in Chromatography and Electrophoresis 1964 (with William H. Stein)
    Nobel Prize for Chemistry 1972 (with Christian Anfinsen and William H. Stein)
    ACS Theodore William Richards Medal 1972 (with William H. Stein)
    CRC LinderstrÝm-Lang Medal 1972 (with William H. Stein)
    American Academy of Arts and Sciences 1960
    American Chemical Society
    American Society for Biochemistry and Molecular Biology Treasurer, 1956-59
    American Society for Biochemistry and Molecular Biology President, 1966
    Belgian Biochemical Society Foreign Member
    Belgian Royal Academy of Medicine Foreign Member
    Biochemical Society
    Harvey Society
    International Union of Pure and Applied Physics
    Journal of Biological Chemistry Editorial Board, 1950-60
    National Academy of Sciences 1960
    Phi Kappa Sigma


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