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Bruce A. Beutler

AKA Bruce Alan Beutler

Born: 29-Dec-1957
Birthplace: Chicago, IL

Gender: Male
Race or Ethnicity: White
Sexual orientation: Straight
Occupation: Biologist

Nationality: United States
Executive summary: Lipopolysaccharide receptors

Fascinated with nature even as a child, Bruce A. Beutler decided at the age of seven that he would be a biologist. He graduated from the University of California at San Diego at age 18, and earned his MD at the University of Chicago. In a series of discoveries beginning in the mid-1980s, Beutler isolated tumor necrosis factor (TNF) in mice, and discovered its inflammatory properties; developed recombinant inhibitors for TNF, which are now used widely as a treatment for inflammatory diseases; and discovered the receptor for lipopolysaccharide (LPS), which helps explain how inflammatory diseases begin and how mammals sense infection. For his work with lipopolysaccharide receptors, Beutler won the Nobel Prize in Physiology or Medicine for 2011, sharing the honor with Jules A. Hoffmann and Ralph M. Steinman.

Father: Ernest Beutler (hematologist, b. 1928, d. 2008)
Mother: Brondelle Fleisher (journalist, m. 1950)
Sister: Deborah Ann Beutler (physician)
Brother: Earl Bryan Beutler (software executive)
Brother: Steven Merrill Beutler (physician)
Wife: Barbara Lanzl (m. circa 1979, div. 1988)
Son: Daniel (b. 1983)
Son: Elliot (b. 1984)
Son: Jonathan (b. 1987)

    High School: Polytechnic School, Pasadena, CA
    University: BA, University of California at San Diego (1976)
    Medical School: MD, University of Chicago (1981)
    Scholar: Residency, University of Texas at Dallas
    Fellow: Rockefeller University (1983-86)
    Teacher: Ass't Prof. of Internal Medicine, University of Texas at Dallas (1986-1990)
    Teacher: Assoc. Prof. of Internal Medicine, University of Texas at Dallas (1990-96)
    Professor: Internal Medicine, University of Texas at Dallas (1996-2000)
    Professor: Genetics, Scripps Research Institute (2000-present)
    Professor: Genetics, University of Texas at Dallas (2011-present)

    FAS Charles Leopold Mayer Prize 2006
    Balzan Prize 2007, with Jules A. Hoffmann
    Shaw Prize in Life Science and Medicine 2011, with Hoffmann and Ruslan Medzhitov
    Nobel Prize for Medicine 2011, with Hoffmann and Ralph M. Steinman
    Howard Hughes Medical Institute Assistant Investigator (1986-91)
    Howard Hughes Medical Institute Investigator (1991-2000)
    American Association of Immunologists
    American Society for Clinical Investigation
    Association of American Physicians
    European Molecular Biology Organization
    Institute of Medicine
    International Mammalian Genome Society
    National Academy of Sciences
    German Ancestry Paternal
    Jewish Ancestry
    Ukrainian Ancestry Maternal

Official Website:
http://www.scripps.edu/research/genetics/faculty.html?name=beutl

Author of books:
Tumor Necrosis Factors (1992, non-fiction)
Immunology, Phenotype First (2007, non-fiction)


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